This study was devised to observe the protective effects of panax ginseng extract (fat-soluble components) on the intoxication of carbon tetrachloride (CCL,).
The male and femal albino rats from pure strain, 192 heads were used for this experiment_ They were divided into six groups; the control, the CC14 injected (CC14 group), the ginseng extract injected (Gx group), the ginseng extract injected after injection Of CC14 (CC14+Gx group), the CC14 injected after injection of ginseng extract (Gx+CCl4 group), the ginseng-extract injected before and after CC14 injection (Gx+CC14+Gx group) groups.
The activity of glutamic pyruvic transaminase (GPT), alkaline phosphatase (Alk P) and_ leucine aminopeptidase (LAP) in serum were determined.
The obtained results are summarized as follows;
1. The activities of GPT have showen essentially the highest value at the 1st day by CC14 injection and the activities of Alk P and LAP were at the 2nd day after administration:. Of CC14 in each group.
2. The variation of enzymes activity was the narrowest in Gx+CC14+Gx group, and CC14. +Gx group was followed by Gx+CC14 group.
3. The activities of Alk P in Gx group was continuously upto 4th day and then returned´ to the level of the control group.
According to the above results, it could be suggested that the CC14 intoxication was, induced to increase the GPT, Alk P and LAP activity level in serum, and the effects of CCI4 treatment were more or less protected and treated by ginseng extract.
|